Our lead projects
To move closer to our vision of a world free of pain, we are currently pursuing a range of programmes across different modalities, targets and mechanisms of action. Here are some selected highlights from our development pipeline.
RTX (resiniferatoxin)
Osteoarthritis (OA) is a progressive condition that currently cannot be cured. The inflamed, swollen and painful joints lead to limitation on mobility of the affected patients and may impact their quality of life significantly. Millions of OA patients currently receive intra-articular corticosteroids or need to undergo knee replacement surgery as last remaining treatment option.
RTX (resiniferatoxin) is an investigational medicine for the intra-articular treatment of pain associated with OA of the knee. Its mechanism of action is well validated and initial data shows a long-lasting and significant analgesic effect and functional improvements compared to placebo (saline injection), as well as a favourable safety profile.
We are currently running a global clinical Phase III programme to investigate the efficacy and safety of intra-articular injections of RTX in adults. Three trials conducted at approx. 200 sites across Europe, the US, Latin America and Japan, will include more than 1800 patients who have exhausted available treatment options for knee osteoarthritis and still suffer from moderate to severe pain. The Phase III programme aims to enable market authorisation in the US, EU and Japan in 2026. We expect to obtain the topline results for the Phase III study and a decision on submission in 2025.
Grünenthal starts Phase III trials for resiniferatoxin in osteoarthritis-related pain. Read more in our Press Release.
Qutenza™ Life Cycle Management
Qutenza™ is a patch containing prescription-strength capsaicin. In Europe, it is approved for the treatment of peripheral neuropathic pain. In the US, it is approved for the treatment of neuropathic pain associated with post-herpetic neuralgia, and in 2020 it also received approval for the treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPN) of the feet in adults.
Our life-cycle management efforts focus on making Qutenza™ more widely available by expanding the label further, particularly in the United States. Specifically, we have started a pivotal Phase III study in post-surgical neuropathic pain. We are also pursuing selected further exploratory activities in other indications with external partners.
MPC-06-ID
In 2019, we have embarked on a partnership with Mesoblast to develop a highly innovative mesenchymal precursor cell therapy for patients with chronic low back pain
associated with degenerative disc disease who have not found effective relief from available treatment options.
Early in 2021, Mesoblast published results from the ongoing Phase III trial MSBDR003 that was carried out in the US and Australia. The trial provided a number of important findings, including a significant and long-lasting treatment effect on pain relief. However, it did not achieve its primary outcome measure between the treatment groups.
After having analysed the data obtained through this trial, Mesoblast anticipates to conduct another confirmatory trial in the US, and to design this trial to support potential parallel product approvals in both the US and Europe.