Non-Opioids

Used to treat mild or moderate pain

The classical analgesics include non-opioid and opioids. Non-opioids are mainly used to treat mild or moderate pain. They can be classified due to their chemical characteristics as acid (NSAIDs = non-steroidal anti-inflammatory drugs such as acetylsalicylic acid (ASA), ibuprofen, diclofenac, naproxen) and non-acid (paracetamol, metamizole).

The common mechanism of action of these substances is their effect on prostaglandin synthesis. Prostaglandins are tissue hormones that can be found in almost all organs. They influence many processes in the body including the widening of blood vessels, pain and inflammation. Non-opioids are able to inhibit prostaglandin synthesis.