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  • Grünenthal reports 2021 full-year results of €1.5 billion in net revenues, an increase of 15 percent.
  • The company delivers €370 million adjusted EBITDA, an increase of 10 percent. EBITDA has nearly tripled since 2017.
  • Several key investments were made in 2021 as part of Grünenthal's growth strategy. This includes closing the acquisition of the established brand Crestor™, acquiring a late-stage pipeline asset (Mestex AG/RTX) and expanding the business with QUTENZA™ in the US.
  • Strong operational performance and financial headroom will enable the company to further invest in targeted M&A and keep moving towards its vision of a world free of pain.


Aachen, Germany, 30 March 2022 – Grünenthal, an international science-driven pharmaceutical company and a leader in pain therapy, has announced its full-year results for 2021. Net revenues reached €1.5 billion, an increase of 15 percent over 2020. Adjusted EBITDA reached €370 million, increasing by 10 percent compared to the prior year. Profitability was driven by robust sales growth, improved production efficiency, and strict cost management. Grünenthal's continued strong performance enabled the company to almost triple its adjusted EBITDA since 2017.

Drivers of the performance were sales in Grünenthal's core markets in Europe and Latin America. Palexia™ continued strong growth in Europe, with sales increasing by 11 percent. In Latin America, the company saw sales growth of its promoted brands following a strategic focus on differentiated pain products.

EBITDA-accreditive M&A deals are a key part of Grünenthal's strategy. In 2021, the company completed the acquisition of the European rights to Crestor™, already showing a substantial sales contribution in its first year. Grünenthal's revenue from the portfolio of acquired brands, including Nexium™, Vimovo™ and Zomig™ has grown by 20 percent compared to the prior year. COVID-19 had a limited impact on Grünenthal's business operations. The company has been able to ensure an uninterrupted supply of medicines to patients worldwide.

"Our people have carried Grünenthal to its best-ever financial performance. We have almost tripled our EBITDA over the last five years and significantly advanced our pipeline, creating fantastic momentum to expand our leadership in pain," says Gabriel Baertschi, CEO and Chairman of the Corporate Executive Board.

Investments in 2021 included measures to strengthen the company's business with QUTENZA™ in the US, where Grünenthal sees significant opportunities for further growth. The company more than doubled its field force for the product that leverages the Nobel Prize-winning discovery of the Transient Receptor Potential Vanilloid 1 (TRPV1).

The company also invested in its development pipeline by acquiring Mestex AG with its innovative investigational medicine Resiniferatoxin (RTX) in April 2021. The promising Phase III asset is developed to provide patients suffering from pain associated with osteoarthritis of the knee with a well tolerable, non-opioid therapy option. It leverages an innovative mechanism of action that also targets the TRPV1 receptor. Grünenthal aims to launch Resiniferatoxin by 2025.

To create additional financial flexibility for the company to invest in future growth, Grünenthal entered the debt capital markets with a €950 million bond. Credit rating agencies validated the company's strategy with strong credit ratings, and demand from investors far exceeded expectations. With the bond, the company extended its debt maturity profile. Around 95 percent of Grünenthal's debt facilities mature in 2026 or later. An Environmental, Social and Governance (ESG) rating agency acknowledged that Grünenthal has a strong management of its ESG risks and placed the company in the top 5 percent of the pharmaceutical sub-industry in March 2021.

"Grünenthal's exceptional operational performance and outlook have been validated by major rating agencies, and the strong investor demand for our bond offering," says Fabian Raschke, Chief Financial Officer of Grünenthal. "The additional financial headroom we generated puts Grünenthal in an excellent position to invest in future growth."

2021 also saw significant progress of key pipeline projects. Grünenthal enrolled the first patients in a Phase III trial to prepare for an extension of QUTENZA™'s US label to include the treatment of post-surgical neuropathic pain. In addition, the company enrolled the first patients in a Phase I trial with its proprietary Glucocorticoid Receptor Modulator (GRM) and conducted an experimental medicine trial with its Nociceptin/Orphanin FQ peptide receptor (NOP) agonist.

On top of the financial performance, Grünenthal made significant progress on its People & Culture strategy. Grünenthal was certified as a Great Place to Work® in eight countries. 81 percent of employees participating in its recent global survey ranked Grünenthal as a great workplace, an increase of 9 percent compared to the previous survey.


About Grünenthal
Grünenthal is a global leader in pain management and related diseases. As a science-based, fully-integrated pharmaceutical company, we have a long track record of bringing innovative treatments and state-of-the-art technologies to patients worldwide. Our purpose is to change lives for the better – and innovation is our passion. We are focusing all of our activities and efforts on working towards our vision of a world free of pain.

Grünenthal is headquartered in Aachen, Germany, and has affiliates in 28 countries across Europe, Latin America and the US. Our products are available in more than 100 countries. In 2021, Grünenthal employed around 4,500 people and achieved sales of € 1.5 bn.


More information:

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Florian Dieckmann, Head Global Corporate Affairs & Communication

Florian Dieckmann

Head Global Corporate Affairs & Communication

Grünenthal GmbH

52099 Aachen


Phone +49 241 569 2555