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Chronic low back pain is defined as the pain that persists for 12 weeks or longer after an injury, disease or stress on different structures of the body. Pain persists with varied intensity from mild to severe.
90% of CLBP cases cannot be attributed to a pathoanatomic cause and are thus referred to as ‘non-specific’.2 53% of patients have to wait more than one year to get the right diagnosis of the cause of their pain.3 64% of patients have to wait more than one year to get adequate pain management.3
It is our ambition to increase responder rates in a stratified sub-population and slow or reverse progression of chronic pain.
We therefore see a need for:
CLBP patients not only experience personal distress and pain, but also present with significant sleep disorders and disability.2 CLBP symptoms include stiffness and muscle tenderness.4 Non-specific terms, such as strain, sprain or degenerative processes, are commonly used. Strain and sprain have never been anatomically or histologically characterised, and patients given these diagnoses might accurately be said to have idiopathic LBP.5,6
CLBP is in the top 5 most prevalent disorders in the EU, with an estimated prevalence of 25M.7 In the US, prevalence has risen in the last decade from 3.9% to 10.2% (32M) of the population.8 Some of the main risk factors for CLBP are occupational hazards e.g. jobs that require repetitive bending, sedentary lifestyle, excess weight and poor posture.9
Pharmacological approaches for CLBP include antidepressants10 and a variety of opioids.11